Crohn's Disease

Crohn's disease is a chronic inflammatory disease of the digestive tract and it can involve any part of it - from the mouth to the anus. It typically affects the terminal ileum as well as demarcated areas of large bowel, with other areas of the bowel being relatively unaffected. It is often associated with auto-immune disorders outside the bowel, such as aphthous stomatitis and rheumatoid arthritis. Crohn's disease should not be confused with a non-progressive and non-degenerative digestive disorder called irritable bowel syndrome. IBS is not an autoimmune disease. Ulcerative colitis is a sibling autoimmune disease to Crohn's but only impacts the colon while Crohn's can impact any part of the digestive tract. Furthermore, Crohn's tends to impact multiple layers of the bowel lining which can lead to many additional and hard to treat complications.

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Allergies

An allergy or Type I hypersensitivity is a immune malfunction whereby a person's body is hypersensitised to react immunologically to typically nonimmunogenic substances. When a person is hypersensitised these substances are known as allergens. The word allergy derives from the Greek words allos meaning "other" and ergon meaning "reaction" or "reactivity". Type I hypersensitivity is characterised by excessive activation of mast cells by immunoglobulin E resulting in a systemic inflammatory response that can result in symptoms as benign as a runny nose, to life-threatening anaphylactic shock and death.

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Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. It is a disabling and painful inflammatory condition, which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and muscles.

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Psoriatic Arthritis

Psoriatic arthritis is a type of inflammatory arthritis that affects around 20% of people suffering from the chronic skin condition Psoriasis. It occurs more commonly in patients with tissue type HLA-B27. Treatment of psoriatic arthritis is similar to that of Rheumatoid arthritis. More than 80% of patients with psoriatic arthritis will have psoriatic nail lesions characterised by pitting of the nails. Psoriatic arthritis is said to be a sero-negative spondyloarthropathy.

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